Bremelanotide may slow gastric emptying and potentially reduces the rate and extent of absorption of concomitantly administered oral medications. Avoid or Use Alternate Drug.īremelanotide will decrease the level or effect of levothyroxine by Other (see comment). Levothyroxine increases effects of bivalirudin by pharmacodynamic synergism. Levothyroxine increases effects of bemiparin by pharmacodynamic synergism. Levothyroxine increases effects of argatroban by pharmacodynamic synergism. Levothyroxine increases effects of antithrombin III by pharmacodynamic synergism. Levothyroxine increases effects of antithrombin alfa by pharmacodynamic synergism. No interaction anticipated with parenteral levothyroxine. Applies only to oral form of both agents. Sucroferric oxyhydroxide decreases levels of levothyroxine by inhibition of GI absorption. Use of thyroid products or iodine before and during treatment with sodium iodide I-131 decreases uptake of sodium iodide I-131 by the thyroid gland Levothyroxine will decrease the level or effect of sodium iodide I-131 by Other (see comment). Start children with severe or chronic hypothyroidism at 25 mcg/day adjust dose by 25 mcg qweek.May minimize hyperactivity in older children by initiating dose at 1/4 of recommended dose increase by that amount each week until full dose achieved.Check for bioequivalence if switching brands/generics.Indicated in patients from birth to 12 years Not indicated for treatment of hypothyroidism during recovery phase of subacute thyroiditis.Not indicated for suppression of benign thyroid nodules and nontoxic diffuse goiter in iodine-sufficient patients, as there are no clinical benefits and overtreatment with levothyroxine may induce hyperthyroidism. IV: Relative bioavailability has not been established use caution when converting patients from PO to IV.Once normalization of thyroid function and serum TSH conc achieved, evaluate q6-12mo.Monitor serum thyroid levels patient may be asymptomatic Monitoring Lower dose of Tirosint capsules may be required compared with standard T4 tablets for hypothyroidism in patients with impaired gastric acid secretion to reach their target TSH levels Tirosint has shown improved absorption compared with conventional T4 tabletsĬheck for bioequivalence if switching brands/generics, OR every week after switching from one levothyroxine sodium preparation to another Fera Pharmaceuticals, LLC 134 Birch Hill Road Locust Valley, NY 11560.Preservation of organ function in brain-dead organ donors Orphan indication sponsor If replacement therapy not initiated, monitor patient annually for clinical status Myxedema Comaģ00-500 mcg IV once, THEN 50-100 mcg qDay until patient is able to tolerate oral administration may consider smaller doses in patients with cardiovascular disease Organ Preservation (Orphan) Initial: 1 mcg/kg PO qDay may be adequate, OR May adjust dose by 12.5-25 mcg q4-6weeks until patient becomes euthyroid and serum TSH concentration normalized adjustments q6-8weeks also usedĪdjust dose by 25 mcg/day q2-4Week PRN Subclinical Hypothyroidism.Usual initial dose: 12.5-25 mcg PO qDay.Injection, lyophilized powder for reconstitutionġ.7 mcg/kg or 100-125 mcg PO qDay not to exceed 300 mcg/day >50 years (or 50 years with CV disease Dosage Forms & Strengths tablet (Levo-T, Levoxyl, Unithroid, generic)
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